Surface chemistry for enhanced bio-compatibility of medical devices: Research and potential commercial devlopment

18.05.2017, Свечана сала Грађевинског факултета у Београду
Предавач: Prof. Michael Tompson
Одељење/Институција: Одељење технолошких, металуршких и наука о материјалима
Our research concerns the development of a chemispassive surface that is being employed to modify a number of conduits and devices used in medicine. The interaction of substrates with the components of biological fluids, especially blood, has constituted a research problem over many years. In this regard, a variety of strategies have been used to attempt an enhancement of biocompatibility with some emphasis being centered on the control of surface free energy and imposition of a plethora of surface coatings. In our work we are addressing the physical chemistry of covalent surface modification through the synthesis of new silane-based molecules. These moieties are bifunctional, medium-chain length trichlorosilanes containing a PEG backbone. (PEG has been the subject of intense study for many years, although its precise role in enhancing biocompatibility has remained elusive.) One of our silanes has shown remarkable properties in terms of the reduction of adsorption of biological entities from serum and blood. The structure of water intercalated in the adlayer appears to be crucial and has been studied in our lab by a number of surface analysis techniques including neutron reflectometry and MD calculation. In particular, we are working on the 5 polymers employed in circuitry used in bypass surgery and renal dialysis and on medical grade stainless steel used for stent technology. It is known that micro-clots can form on polymers leading to medical consequences such as cognitive disability. Research collaboration with the Likah Sheng Institute of St. Michael’s Hospital involving real time confocal spectroscopy of the polymer surface-blood interaction shows a 98 % reduction of thrombus formation for our surface modification. The Chemistry outlined above has been allowed recently as a full USA patent. A Company has been formed to exploit the technology in the medical field. We will discuss briefly the marketplace for surface-enhanced medical devices and plans for commercial development both in Canada and the USA. Позив за предавање
Предавач: Prof. Michael Tompson
Prof. dr MICHAEL THOMPSON, redovni profesor sa Univerziteta u Torontu rukovodi naučno-istraživačkim grupama u okviru Instituta za biomaterijale i biomedicinski inženjering i Katedre za hemiju. Fokus naučnih istraživanja prof. Thompsona je hemija (analitička i bioanalitička hemija) i interdisciplinarna povezivanja hemije sa inženjerstvom iz oblasti biomedicine, mikroelektronike, fizike, analize površina i organske hemije (sinteze). Prof. Thompson je član Hemijskog instituta Kanada (FCIC), [društva koje organizaciono objedinjuje: Kanadsko društvo hemičara (CSC), Kanadsko društvo hemijskih inženjera (CSSE) i Kanadsko društvo hemijskih tehnologa (CSCT)]; Kraljevskog društva Kanada (FRC). Redovni je član Akademije nauka Irske. Prof Thompson je imao kontinuiranu saradnju (30 godina) sa Beogradskim univerzitetom, TMF-om i Katedrom za analitičku hemiju, grupom za hemijske senzore (prof. Lj.Rajaković).
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